Depakote or seroquel which more sedating
Despite the risks of antipsychotics, family members are often anxious to get some relief as soon as possible.
As for residential facilities for people with Alzheimer’s and other dementias, they vary in how well their staff are trained in non-drug approaches.
: A review of randomized trials of valproate for agitation in dementia found no evidence of clinical efficacy, and described the rate of adverse effects as “unacceptable.” Despite this, some geriatric psychiatrists and other experts feel that valproate works well to improve behavior in certain people with dementia. SSRIs may help some individuals, but it usually takes weeks or longer to see an effect.
For some people, a sedating antidepressant at bedtime can improve sleep and this may reduce daytime irritability.
In many cases, antipsychotics and other tranquilizing medications can certainly calm the behaviors.
But they can have significant side-effects and risks, which are often not explained to families.
This is sometimes described as a “chemical restraint” (as opposed to tying people to a chair, which is a “physical restraint”).One of the greatest challenges, when it comes to Alzheimer’s disease and other dementias, is coping with difficult behaviors.These are symptoms beyond the chronic memory/thinking problems that are the hallmark of dementia.: A 2014 randomized trial found that citalopram provided a modest improvement in neuropsychiatric symptoms; however the dose used was 30mg/day, which has since been discouraged by the FDA. These are the drugs FDA-approved to treat the memory and thinking problems associated with Alzheimer’s disease.Otherwise, clinical studies suggest that antidepressants are not very effective for reducing agitation. In some patients they seem to help with certain neuropsychiatric symptoms.